I have a 2010 Hemi with AFE intake, 180 thermo, and gibson exhaust. I have had a Predator for over a year and have tried mult settings and tunes. I have it on the 93 oct tune and there is a definite improvement over the regular tune. I also shut off the MDS and noticed minimal loss of fuel mileage. I also increased the throttle boost, as I prefer a sensitive throttle. The adjustments to shift points have probably made the biggest difference in overall driveability, however, with raising them at all available throttle openings.
Enjoy the various options and try out different settings to see what works for you!